Effective Oct 1, 2021, immigrants applying for adjustment of status with USCIS must be fully vaccinated against the COVID-19 virus. Generally, a person applying for lawful permanent residence must show they are not disqualified based on health grounds. For this reason, USCIS requires a medical exam conducted by an authorized doctor and other vaccinations (such as polio, tetanus, measles) for applications of permanent residence. Due to the pandemic crisis, applicants are now required to provide documentation of COVID-19 vaccination at the medical exam for immigration purposes.
There are some important exceptions to this vaccination requirement. The COVID-19 vaccination is not required If the vaccination is not age appropriate; the vaccination cannot be given for medical reasons; or there is a limited supply of vaccination.
There is also a waiver for the COVID-19 vaccination requirement if the applicant refuses vaccination based on religious or moral convictions. The applicant must submit a waiver form along with the application packet to qualify.
Source: USCIS – https://www.uscis.gov/news/alerts/covid-19-vaccination-required-for-immigration-medical-examinations